Novel phosphine-phosphite and phosphine-phosphinite ligands for highly enantioselective asymmetric hydrogenation

作者：Yan YJ; Chi YX; Zhang XM^*

来源：Tetrahedron: Asymmetry , 2004, 15(14): 2173-2175.

DOI：10.1016/j.tetasy.2004.04.013

Two novel phosphine-phosphite (S,R)-o-BINAPHOS and phosphine-phosphinite (S)-o-BIPNITE ligands based on ortho phenyl substituted (S)-BINOL have been synthesized. Extremely high enantioselectivity (over 99% ee in most cases) has been achieved for the Rh-catalyzed asymmetric hydrogenation of alpha-dehydroamino acid derivatives.

• 出版日期2004-7-26