A risk stratifying tool to facilitate safe late-stage percutaneous endoscopic gastrostomy in ALS

作者：Thompson Alexander G; Blackwell Victoria; Marsden Rachael; Millard Emma; Lawson Clare; Nickol Annabel H; East James E; Talbot Kevin; Allan Philip J^*; Turner Martin R^*

来源：Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2017, 18(3-4): 243-248.

DOI：10.1080/21678421.2016.1274330

• Nutrition
• gastrostomy
• PEG
• treatment
• management

Background: The safety of percutaneous endoscopic gastrostomy (PEG) insertion in amyotrophic lateral sclerosis (ALS) patients with significant respiratory compromise has been questioned. Objectives: To review the characteristics of an ALS clinic patient cohort undergoing PEG, and the introduction of a risk stratification tool with procedural adaptations for higher-risk individuals. Methods: Patients undergoing PEG insertion were analysed (n=107). Cases stratified as higher-risk underwent insertion in a semi-recumbent position, minimising sedation, with the option of nasal non-invasive ventilation. Results: All underwent successful PEG. One-third had pre-procedure FVC 50% (mean, 64 +/- 22%). Of those who underwent PEG insertion after introduction of risk stratification (n=58), 39 (67%) met criteria for being higher risk, 16 (41%) of whom had FVC 50% (p=0.005). High-risk patients received lower sedative doses vs. the low-risk group (midazolam 2.1 +/- 1.1 vs.2.8 +/- 0.95mg, p=0.021; fentanyl 42 +/- 16 vs. 60 +/- 21g, p=0.015). Four deaths occurred within one month of insertion (attributable to the natural disease course). Conclusions: Risk stratification identified a greater number of patients with evidence of respiratory compromise than using the sole criterion of FVC 50%. A modified PEG procedure enabled safe insertion despite respiratory compromise, in those who might not have tolerated attempted insertion by alternative means such as radiologically-inserted gastrostomy.

• 出版日期2017