科研之友
微信
新浪微博
Facebook
分享链接
摘要
The preparation of a series of new prochiral bis-alkynes is reported. A selection of chiral ligands is examined to gain additional information about the scope of the new asymmetric Huisgen click%26apos; reaction [the desymmetrisation of bis-alkynes using chiral ligands in conjunction with the widely applied copper-catalysed azide-alkyne cycloaddition (CuAAC) triazole synthesis]. The development of a new chiral assay for (+/-)-methyl 2-[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]-2-cyanopent-4-ynoate, and the production of this mono-triazole in up to 18% enantiomeric excess is described.
- 出版日期2013-12-17
