Antimicrobial Resistance in Hospital-Acquired Gram-Negative Bacterial Infections

作者：Mehrad Borna; Clark Nina M; Zhanel George G; Lynch Joseph P III^*

来源：Chest, 2015, 147(5): 1413-1421.

DOI：10.1378/chest.14-2171

Aerobic gram-negative bacilli, including the family of Enterobacteriaceae and non-lactose fermenting bacteria such as Pseudomonas and Acinetobacter species, are major causes of hospital-acquired infections. The rate of antibiotic resistance among these pathogens has accelerated dramatically in recent years and has reached pandemic scale. It is no longer uncommon to encounter gram-negative infections that are untreatable using conventional antibiotics in hospitalized patients. In this review, we provide a summary of the major classes of gram-negative bacilli and their key mechanisms of antimicrobial resistance, discuss approaches to the treatment of these difficult infections, and outline methods to slow the further spread of resistance mechanisms.

• 出版日期2015-5