Novel approach to the synthesis of aliphatic and aromatic alpha-keto acids

作者：Balducci Daniele; Conway Philip A; Sapuppo Giulia; Mueller Bunz Helge; Paradisi Francesca^*

来源：Tetrahedron, 2012, 68(36): 7374-7379.

DOI：10.1016/j.tet.2012.06.078

• alpha-Keto acids
• Aromatic
• Aliphatic
• Aldol reaction

A new practical and efficient synthesis of alpha-keto acids was accomplished starting from the synthon 1,4-diacetylpiperazine-2,5-dione. The synthesis encompasses both aromatic and aliphatic substrates proving to be versatile and innovative with excellent carbon economy and recycling of the glycine by-product.

• 出版日期2012-9-9