Design and synthesis of 3-(2-cinnamamidoethylsulfonyl) thiazolidine-4-carboxylate derivatives as novel angiotensin converting enzyme (ACE) inhibitors

作者：Wu Leifang; Zhang Jie; Xie Jianwei^*; Dai Bin

来源：Journal of Chemical and Pharmaceutical Research, 2014, 6(3): 1205-1211.

• 3-(2-cinnamamidoethylsulfonyl) thiazolidine-4-carboxylate
• Angiotensin converting enzyme inhibitor (ACE)
• Angiotensin-converting enzyme
• Hypertension
• Inhibitory activity
• Potent activity

A series of 3-(2-cinnamamidoethylsulfonyl)thiazolidine-4-carboxylate derivatives were designed, synthesized, and evaluated for their angiotensin converting enzyme (ACE) inhibitory activity. Their structures were verified by 1H NMR, 13C NMR, IR, and MS. All these compounds exhibited inhibitory activity against ACE with IC50 value of 3-9 mM, and 10g showed the most potent activity.

• 出版日期2014
• 单位石河子大学