Dress syndrome. Report of nine cases

作者：Ocampo Garza Jorge^*; Sofia Ocampo Garza Sonia; Dario Martinez Villarreal Jose; Elena Barbosa Moreno Laura; Antonio Guerrero Gonzalez Guillermo; Ocampo Candiani Jorge

来源：Revista Medica de Chile, 2015, 143(5): 577-583.

• Dexamethasone
• Drug eruptions
• Drug hypersensitivity syndrome

Background: DRESS Syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) is an uncommon disease caused by drugs. It is characterized by a polymorphic disseminated eruption with fever and multiple organ dysfunction. Aim: To report the etiology, characteristics, treatment, prognosis, and follow up of patients with DRESS Syndrome admitted to a clinical hospital. Material and Methods: Review of medical records of patients admitted for drug reactions, selecting those patients complying with clinical criteria for DRESS Syndrome. Drugs used during three months prior to the onset of symptoms were evaluated as possible causes of the disease. Results: Nine patients aged 16 to 68 years (six males) complied with the clinical criteria for the disease. The causative medications were carbamazepine in three patients, phenytoin in three, antituberculous drugs in two and amoxicillin in one. All were treated with systemic steroids with a complete clinical resolution. Conclusions: DRESS syndrome is usually underdiagnosed and has a good response to systemic steroids.

• 出版日期2015-5