Autophagy: A Sweet Process in Diabetes

作者:Meijer Alfred J*; Codogno Patrice
来源:Cell Metabolism, 2008, 8(4): 275-276.
DOI:10.1016/j.cmet.2008.09.001

摘要

Autophagy is inhibited by the insulin-amino acid-mTOR signaling pathway. Two papers in this issue of Cell Metabolism (Ebato et al., 2008; Jung et al., 2008) provide evidence that basal autophagy is necessary to maintain the architecture and function of pancreatic beta cells and that its induction in diabetic mice protects beta cells against damage by oxidative stress.

  • 出版日期2008-10-8