UTILIZATION OF 2'-DEOXY-6-THIOGUANOSINE 5'-TRIPHOSPHATE IN DNA-SYNTHESIS CATALYZED BY DNA-POLYMERASE-I KLENOW FRAGMENT OF ESCHERICHIA-COLI

作者：LING YH^*; NELSON JA; FARQUHAR D; BEATTIE KL

来源：Nucleosides and Nucleotides, 1992, 11(1): 23-35.

DOI：10.1080/07328319208021150

The substrate kinetics of 2'-deoxy-6-thioguanosine 5'-triphosphate for DNA polymerase I (Klenow fragment) of Escherichia coli were investigated. The analog nucleotide was readily incorporated in place of dGTP and it was misincorporated in place of dATP at low but detectable frequency.

• 出版日期1992