科研之友
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摘要
Background: Previous study has indicated association between REG1 alpha and bladder cancer. The aim of this study was to investigate the role of Regenerating gene I alpha (REG1 alpha) in bladder cancer. @@@ Methods: The role of REG1 alpha in bladder cancer cell proliferation, migration and VEGF-induced angiogenesis was explored in vitro and in vivo. Immunohistochemistry (IHC) analysis was assessed to determine the expression of REG1 alpha in ten paired bladder cancer and adjacent non-cancerous tissues, and in 296 bladder cancer samples. @@@ Results: Down-regulation of REG1 alpha expression significantly reduced the proliferation, migration, invasion and VEGF-induced angiogenesis in vitro and the growth of xenograft tumors in vivo. VEGF expression in bladder cancer is associated with REG1 alpha expression and recurrence. REG1 alpha was overexpressed in bladder cancer tissues compared with adjacent normal samples. Patients with elevated REG1 alpha exhibited shorter recurrence times and poor survival. @@@ Conclusion: Downregulation of REG1 alpha expression can reduce tumor growth, migration, invasion and angiogenesis. Our study demonstrates that REG1 alpha can be used as a marker of recurrence and prognosis in bladder cancer. Therefore, REG1 alpha targeting in bladder cancer patients represents a promising therapeutic strategy.
