An implantable thermoresponsive drug delivery system based on Peltier device

作者：Yang Rongbing^*; Gorelov Alexander V; Aldabbagh Fawaz; Carroll William M; Rochev Yury

来源：International Journal of Pharmaceutics, 2013, 447(1-2): 109-114.

DOI：10.1016/j.ijpharm.2013.02.051

• Controlled release
• Thermoresponsive
• Local cooling
• Peltier
• Implantable

Locally dropping the temperature in vivo is the main obstacle to the clinical use of a thermoresponsive drug delivery system. In this paper, a Peltier electronic element is incorporated with a thermoresponsive thin film based drug delivery system to form a new drug delivery device which can regulate the release of rhodamine B in a water environment at 37 degrees C. Various current signals are used to control the temperature of the cold side of the Peltier device and the volume of water on top of the Peltier device affects the change in temperature. The pulsatile on-demand release profile of the model drug is obtained by turning the current signal on and off. The work has shown that the 2600 mAh power source is enough to power this device for 1.3 h. Furthermore, the excessive heat will not cause thermal damage in the body as it will be dissipated by the thermoregulation of the human body. Therefore, this simple novel device can be implanted and should work well in vivo.

• 出版日期2013-4-15