摘要
Although a new matrix formulation fentanyl has been used throughout the world for cancer pain management, few data about its efficacy and clinical outcomes associated with its use in Chinese patients have been obtained. This study aimed to assess the efficacy and safety of the new system in Chinese patients with moderate to severe cancer pain. @@@ A total of 474 patients with moderate to severe cancer pain were enrolled in this study and were treated with the new transdermal fentanyl matrix patch (TDF) up to 2 weeks. All the patients were asked to record pain intensity, side effects, quality of life (QOL), adherence and global satisfaction. The initial dose of fentanyl was 25 mu g/h titrated with opioid or according to National Comprehensive Cancer Network (NCCN) guidelines. Transdermal fentanyl was changed every three days. @@@ After 2 weeks. The mean pain intensity of the 459 evaluated patients decreased significantly from 5.63 +/- 1.26 to 2.03 +/- 1.46 (P < 0.0001). The total remission rate was 91.29%, of which moderate remission rate 53.16%, obvious remission rate 25.49% and complete remission rate 12.64%. The rate of adverse events was 33.75%, 18.78% of which were moderate and 3.80% were severe. The most frequent adverse events were constipation and nausea. No fatal events were observed. The quality of life was remarkably improved after the treatment (P < 0.0001). @@@ The new TDF is effective and safe in treating patients with moderate to severe cancer pain, and can significantly improve the quality of life.
- 出版日期2011-12
- 单位武汉市中西医结合医院; 中国医科大学; 北京大学; 中国人民解放军陆军总医院; 浙江大学; 浙江省肿瘤医院; 中国人民解放军总医院; 广东药科大学; 青岛大学; 北京市肿瘤防治研究所; 湖北省肿瘤医院; 天津市人民医院