Antimicrobial, anticancer and DNA binding studies of transition metal(II) complexes containing 2-phenyl-4-selenazole carboxylic acid

作者：Guan QuanYin; Shi Xia; Shen JinBei; Zhao GuoLiang^*

来源：Science China Chemistry, 2013, 56(5): 588-594.

DOI：10.1007/s11426-012-4814-4

• 2-phenyl-4-selenazole carboxylic acid
• transition metal complex
• antibacterial activity
• anticancer activity
• DNA binding

Three novel transition metal complexes [ML2(phen)]center dot H2O (M= Mn, Co, Zn; HL= C10H7O2NSe, 2-phenyl-4-selenazole carboxylic acid, phen= 1,10-phenanthroline) 1 similar to 3 were synthesized and characterized by elemental analysis, IR spectra. Their crystal structures were deterimined by single-crystal X-ray diffraction method. The antibacterial activities of the complexes against five species of bacteria, Escherichia coli (E. coli), Staphylococcus epidermidis (S. epidermidis), Staphylococcus aureus (S. aureus), Acinetobacter baumanii (A. baumanii) and Streptococcus viridans (S. viridans), were tested respectively. The anticancer activities of the complexes against human pancreatic cancer line PANC-28 and human hepatocarcinoma line HuH7 were also studied. The interactions between the complexes and DNA were studied by ethidium bromide (EB) fluorescent probe.

• 出版日期2013-5
• 单位浙江师范大学