United States voluntary children's chemical evaluation program (VCCEP) risk assessment for children exposed to benzene

作者：Pyatt David W^*; Hays Sean M; English Christine; Cushing Colleen A

来源：Toxicology Mechanisms and Methods, 2012, 22(2): 81-104.

DOI：10.3109/15376516.2011.596232

• Cancer
• leukemia
• AML
• US EPA
• margin of safety
• risk assessment

As part of the Voluntary Children's Chemical Evaluation Program (VCCEP) program, a risk assessment was performed to evaluate the risks to children from environmental benzene exposures. This paper summarizes this risk assessment. Risk was characterized using two distinct methods: USEPA's default type of risk assessment, which used the Reference Dose (RfD) and Cancer Slope Factor (CSF) to characterize non-cancer and cancer risks, as well as a Margin of Safety (MOS) approach that utilized a point of departure (POD). The exposures for most scenarios evaluated in this VCCEP risk assessment are lower than both the cancer and non-cancer PODs by several orders of magnitude, indicating a large MOS and corresponding low potential for toxicity at these exposures. The highest benzene exposures likely experienced by children, associated with the lowest MOS, are from cigarette smoke. In addition, the potential for age-related differences in the sensitivity towards benzene-induced toxicity was investigated. In general, this risk assessment does not indicate that children are likely to be at a elevated risk of AML or hematopoietic toxicity associated with environmental exposures to benzene.

• 出版日期2012-2