Associations between single-nucleotide polymorphisms (+45T > G,+276G > T,-11377C > G,-11391G > A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis

作者：Han L Y; Wu Q H^*; Jiao M L; Hao Y H; Liang L B; Gao L J; Legge D G; Quan H; Zhao M M; Ning N; Kang Z; Sun H

来源：Diabetologia, 2011, 54(9): 2303-2314.

DOI：10.1007/s00125-011-2202-9

• Adiponectin
• ADIPOQ
• Gene
• Meta-analysis
• SNP
• Systematic review
• Type 2 diabetes mellitus

The associations between adiponectin polymorphisms and type 2 diabetes have been studied widely; however, results are inconsistent.
We searched electronic literature databases and reference lists of relevant articles. A fixed or random effects model was used on the basis of heterogeneity. Sub-group and meta-regression analyses were conducted to explore the sources of heterogeneity.
There were no statistically significant associations between +45T > G (rs2241766), +276G > T (rs1501299), -11391G > A (rs17300539) and type 2 diabetes risk. However, for -11377C > G (rs266729), the pooled OR (95% CI) for G vs C allele was 1.07 (1.03-1.11, p = 0.001). Subgroup analysis by study design revealed that -11377C > G (rs266729) dominant model (CG+GG vs CC, p = 0.0008) and G vs C allele (p = 0.0004) might be associated with type 2 diabetes risk in population-based case-control studies. After stratification by ethnicity, we found that -11377C > G (rs266729) dominant model (CG+GG vs CC, p = 0.004) and G vs C allele (p = 0.001) might be associated with type 2 diabetes risk in white individuals. In individuals with a family history of diabetes, the presence of -11391G > A (rs17300539) dominant model (GA+AA vs GG) and A vs G allele might be associated with increased risk of type 2 diabetes.
The presence of +45T > G (rs2241766), +276G > T (rs1501299) and -11391G > A (rs17300539) do not appear to influence the development of type 2 diabetes. However, G vs C allele of -11377C > G (rs266729) might be a risk factor for type 2 diabetes.

• 出版日期2011-9
• 单位哈尔滨医科大学