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摘要
<jats:p>Evidence is mounting for a role for neutrophils in breast cancer progression to metastasis. However, the role of G‐<jats:styled-content style="fixed-case">CSF</jats:styled-content> in neutrophil biology in a cancer setting remains to be defined. Herein we discuss the most recent clinical and experimental evidence for neutrophils and G‐<jats:styled-content style="fixed-case">CSF</jats:styled-content> in the promotion of metastasis, demonstrating a potential mechanistic link between them. Understanding this link is imperative both for the development of diagnostic tests and for therapies targeting neutrophils to improve the treatment of breast cancer patients with or at risk of developing metastatic disease. As a high neutrophil‐to‐lymphocyte ratio in patients predicts poor outcome, while mild neutropenia predicts an improved outcome, we urge caution in the use of G‐<jats:styled-content style="fixed-case">CSF</jats:styled-content> in neutrophil recovery following chemotherapy as there is increasing evidence in preclinical models that G‐<jats:styled-content style="fixed-case">CSF</jats:styled-content> can promote metastasis.</jats:p>
- 出版日期2018-2
