A new entry of highly nucleophilic CHBr3-TiCl4-Mg system for the stereoselective synthesis of 1-alkenyl bromides

作者：Bhorge Yeshwant Ramchandra; Chang Su Haur; Chang Cheng Ta; Yan Tu Hsin^*

来源：Tetrahedron, 2012, 68(24): 4846-4851.

DOI：10.1016/j.tet.2012.03.123

This TiCl4-Mg promoted coupling of CHBr3 with various aldehydes and ketones, especially in sterically hindered or enolizable ketones, provides a simple, practical, and stereoselective carbonyl-bromomethylenation leading primarily to (E)-vinyl bromides.

• 出版日期2012-6-17