A Multicomponent Coupling Sequence for Direct Access to Substituted Quinolines

作者：Majumder Supriyo; Gipson Kevin R; Odom Aaron L^*

来源：Organic Letters, 2009, 11(20): 4720-4723.

DOI：10.1021/ol901855b

A titanium-catalyzed three-component coupling reaction can be used to generate tautomers of N-aryl-1,3-diimines. Simple treatment of these products with acetic acid leads to cyclization forming quinoline derivatives in a one-pot procedure. The primary amines employed can be substituted anilines, aminonaphthalenes, or even heterocyclic amines, which leads to a variety of fused-ring heterocyclic frameworks. The one-pot yields varied from 25-71% for the 18 examples presented in this study.

• 出版日期2009-10-15