Duct-to-duct biliary reconstruction in patients with primary sclerosing cholangitis undergoing liver transplantation

作者：Esfeh Jamak Modaresi; Eghtesad Bijan^*; Hodgkinson Peter; Diago Teresa; Fujiki Masato; Hashimoto Koji; Quintini Cristiano; Aucejo Federico; Kelly Dympna; Winans Charles; Vogt David; Miller Charles; Zein Nizar; Fung John

来源：Hepato Pancreato Biliary, 2011, 13(9): 651-655.

DOI：10.1111/j.1477-2574.2011.00346.x

• surgical technique &lt
• transplant
• outcomes &lt
• liver transplantation &lt
• biliary complications

Background: Reconstruction of biliary drainage after liver transplantation (LTx) in patients with primary sclerosing cholangitis (PSC) has been a matter of controversy. Over recent years, the traditional method of Roux-en-Y hepaticojejunostomy (RY) has been challenged by duct-to-duct (DD) biliary reconstruction.
Methods: This study represents a retrospective review of biliary complications, patient and graft survival after LTx in PSC patients based on type of biliary reconstruction. Outcomes of DD reconstruction in this group of patients and non-PSC patients are compared.
Results: A total of 53 primary LTx procedures were performed for PSC between August 2005 and July 2010. Seven patients were excluded because unexpected cholangiocarcinoma was found in the explants (n = 3) or because they received partial livers (n = 4). Biliary reconstruction was performed as DD in 18 patients and RY in 28 patients. There were no bile leaks. Anastomotic stricture occurred in two (11%) patients in the DD group and one (4%) in the RY group. Two (7%) patients in the RY group developed non-PSC intrahepatic strictures and one had recurrence of PSC. Rates of 1- and 3-year patient and graft survival in the RY and DD groups were 96.7% and 96.7%, and 100% and 94.5%, respectively. In a group of 34 randomly selected patients transplanted for a non-PSC diagnosis with DD reconstruction during the same period, the anastomotic stricture rate was 9% and 1- and 3-year patient and graft survival rates were 97.0% and 88.5%; differences were not significant.
Conclusions: Duct-to-duct biliary reconstruction at the time of LTx in selected PSC patients is both effective and safe, and shows outcomes comparable with those of RY reconstruction in these patients and those of DD reconstruction in non-PSC patients.

• 出版日期2011-9