Morphological changes of the trabecular bone in osteonecrosis of the femoral head

作者：Yang, Fan; Zhu, Zhen-Zhong; Weng, Shi-Yang; Gao, You-Shui; Wang, Yang; Sheng, Jia-Gen^*; Zhang, Chang-Qing^*

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(4): 4203-4211.

• Osteonecrosis of the femoral head
• Micro-CT
• pathologic morphology

This study compared the differences between the three-dimensional structure of normal trabecular bone and osteonecrosis necrosis of the femoral head (ONFH) from different causes. Specimens from 12 patients with ONFH were collected after total hip arthroplasty (Ficat II) and six specimens were collected from a group with fractures of the femoral neck. Micro-computer tomography (micro-CT) scans were performed on all specimens and the morphological parameters of different regions of the trabecular bone were measured. The patients were divided into the following three groups: idiopathic group, corticosteroids group and fracture group. In the fracture group, the trabecular bone volume fraction (BV/TV) and structure model index (SMI) were significantly higher than that of the other two groups (P < 0.05). The results among groups in various regions of the bone showed that the BV/TV in idiopathic group and corticosteroids group was below that in the fracture group. Meanwhile, the trabecular bone spacing in the first two groups was higher than that in the fracture group. Within each group, the morphology of the trabecular bone in the idiopathic group and corticosteroids group substantially changed according to the different region of the bone. Our studies demonstrated that ONFH results in structural disorders of the trabecula and loss of bone mass, especially in the corticosteroids group. The trabecular bone structure under the cartilage is remarkably different in different regions of the bone. Between the necrosis and repair areas, a large difference in trabecular morphology might be the key to fractures and collapse.

• 出版日期2016
• 单位上海交通大学