A polygenic model with common variants may predict lung adenocarcinoma risk in humans

作者：Galvan Antonella; Falvella Felicia S; Spinola Monica; Frullanti Elisa; Leoni Vera P; Noci Sara; Alonso Maria R; Zolin Anna; Spada Elena; Milani Silvano; Pastorino Ugo; Incarbone Matteo; Santambrogio Luigi; Neira Anna Gonzalez; Dragani Tommaso A^*

来源：International Journal of Cancer, 2008, 123(10): 2327-2330.

DOI：10.1002/ijc.23789

• lung adenocarcinoma
• smoking
• genetic susceptibility
• single-nucleotide polymorphisms
• genome-wide association

Genome-wide screening for genetic loci associated with risk of lung adenocarcinoma (ADCA) was carried out in pooled DNA using the Illumina 300K single-nucleotide polymorphism (SNIP) array, in a joint analysis of 2 Italian case-control series matched by age, gender and smoking habit. The rare allele carrier status of 8 SNPs was associated with a decreased lung ADCA risk [odds ratios (OR): 0.6-0.8]. In a polygenic model characterized by additive and interchangeable effects, individuals carrying 2 to 6 rare alleles at these 8 SNPs showed a significant trend toward a decreased risk of lung ADCA (up to OR of 0.3). These results suggest the relevance of a polygenic model in the modulation of individual risk of lung ADCA in the general population.

• 出版日期2008-11-15