科研之友
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摘要
The D-series resolvins are known as endogenous lipid mediators biosynthesized from docosahexaenoic acid, and play an important role in numerous pharmacological actions like limiting the neutrophil migration, increasing the resolution rate of the acute inflammation, restoration of tissue homeostasis, etc. Recently, Resolvin D1 was proposed to interact to an orphan G-protein coupled receptor (GPCR) - GPR32, being a potential candidate for the natural ligand of this receptor. This new findings are analyzed and discussed in the present work by comparing the protein distances and similarities between GPR32 and characterized GPCRs using computational chemistry techniques based on phylogeny, amino acid conservation and diversity, ligand similarity, etc. Small variation regarding the topology of the phylogenetic trees were noticed when receptors were cluster based on sequence or sequence fragments. In contrast, ligand similarities induce considerable changes in phylogenetic topologies and protein distances but despite this aspect, FPR2 receptor still shows the strongest relatedness with GPR32 orphan.
- 出版日期2014-4
