A feedback glucose control strategy for type II diabetes mellitus based on fuzzy logic

作者：Ekram F; Sun L; Vahidi O; Kwok E^*; Gopaluni R B

来源：Canadian Journal of Chemical Engineering, 2012, 90(6): 1411-1417.

DOI：10.1002/cjce.21667

• Type II diabetes mellitus
• feedback control
• fuzzy inference system

Most patients with severe Type II diabetes mellitus, characterised by both insulin resistance and beta-cell failure, eventually require insulin therapy. According to the nonlinear dynamics of homeostasis of blood glucose, proportional-integral (PI) controller, modified by penalising the feedback error using a fuzzy inference system has been developed to maintain normoglycaemia in a simulated patient using a closed-loop insulin infusion pump. The simulation employs a compartment model proposed by Vahidi et al. [Vahidi et al., Biochem. Eng. J. 2011, 55(1), 716]. The results demonstrate that the fuzzy-based PI controller is superior to a conventional PI controller for the regulation of blood glucose by insulin infusion for Type II diabetic patients.

• 出版日期2012-12