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摘要
An efficient method for the preparation of 4-substituted 4-hydroxyisoquinoline-1,3(2H,4H)-diones has been developed. Thus, treatment of N-alkyl-2,N-dilithiobenzamides, generated by treating N-alkylbenzamides with two equivalents of butyllithium, with methyl 2-oxoalkanoates resulted in the formation of the desired products in one pot in satisfactory yields.
- 出版日期2017-6-1
