科研之友
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摘要
An efficient and facile method for the synthesis of N-substituted pyrroles in moderate to good yields by the Paal-Knorr reaction of gamma-diketones with amines in the presence of beta-cyclodextrin in aqueous media has been developed. Moreover, this process tolerated diamines (e.g., para-, meta- or ortho-phenylenediamine) to construct bis-pyrrole or mono-pyrrole derivates. beta-Cyclodextrin can be recovered easily after the reactions and reused without evident loss in activity.
