Analytical investigation of bilayer lipid biosensor based on graphene

作者：Akbari Elnaz; Buntat Zolkafle^*; Shahraki Elmira; Parvaz Ramtin; Kiani Mohammad Javad

来源：Journal of Biomaterials Applications, 2016, 30(6): 677-685.

DOI：10.1177/0885328215585682

• Monolayer graphene
• lipid bilayer
• conductance
• artificial neural network
• support vector regression
• GFET

Graphene is another allotrope of carbon with two-dimensional monolayer honeycomb. Owing to its special characteristics including electrical, physical and optical properties, graphene is known as a more suitable candidate compared to other materials to be used in the sensor application. It is possible, moreover, to use biosensor by using electrolyte-gated field effect transistor based on graphene (GFET) to identify the alterations in charged lipid membrane properties. The current article aims to show how thickness and charges of a membrane electric can result in a monolayer graphene-based GFET while the emphasis is on the conductance variation. It is proposed that the thickness and electric charge of the lipid bilayer (L-LP and Q(LP)) are functions of carrier density, and to find the equation relating these suitable control parameters are introduced. Artificial neural network algorithm as well as support vector regression has also been incorporated to obtain other models for conductance characteristic. The results comparison between analytical models, artificial neural network and support vector regression with the experimental data extracted from previous work show an acceptable agreement.

• 出版日期2016-1