ANTIFUNGAL AND CYTOTOXIC ACTIVITIES OF NANNORRHOPS RITCHIANA ROOTS EXTRACT

作者：Rashid Rehana^*; Mukhtar Farah; Khan Abida

来源：Acta Poloniae Pharmaceutica, 2014, 71(5): 789-793.

• Nannorrhops ritchiana
• antifungal activity
• brine shrimp
• cytotoxic activity

This study was designed to evaluate the antifungal and cytotoxic activities of the Nannorrhops ritchiana (Mazari Palm) 80% methanol extract (NR-M) and its four crude extracts i.e., petroleum ether (NR-A), dichloromethane (NR-B), ethyl acetate (NR-C) and butanol (NR-D). The antifungal activity was determined by agar tube dilution method against nine fungal strains; Aspergillus flavus, Trichophyton longifusis, Ttichophyton mentagrophytes, Aspergillus flavor and Microsporum canis were susceptible to the extracts with percentage inhibition of (70-80%). Extracts exhibited significant and good antifungal activity against various fungal strains. The results were deduced by comparing with those for miconazole, amphotericin B and ketoconazole as standard drugs. The fractions of methanolic extract were assayed for their brine shrimp cytotoxic activity. They exhibited low toxicity with LC50 values ranging from 285.7 to 4350.75 mu g/mL at the concentration of obtained results warrant follow up through bioassay guided isolation of the active principles, future antiinfectious research.

• 出版日期2014-10