A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging

作者:Doria F; Nadai M; Zuffo M; Perrone R; Freccero M*; Richter S N*
来源:Chemical communications, 2017, 53(14): 2268-2271.
DOI:10.1039/c6cc08492c

摘要

Aggregation, red-NIR emission and light-up upon nucleic acid G-quadruplex binding have been investigated for a prototype core-extended naphthalene diimide, which is capable of fast cellular entry and nucleolar localization. Both high-level colocalization with an anti-G-quadruplex antibody and nucleolin displacement reveal that the compound targets and thus makes visible nuclear DNA G-quadruplexes.

  • 出版日期2017