A mild and efficient method for nucleophilic aromatic fluorination using tetrabutylammonium fluoride as fluorinating reagent

作者：Hu Yu Feng; Luo Jun; Lue Chun Xu

来源：Chinese Chemical Letters, 2010, 21(2): 151-154.

DOI：10.1016/j.cclet.2009.10.014

• TBAF(anh.)
• Fluoroaromatics
• Fluorodenitration
• Halex

Anhydrous tetrabutylammonium fluoride (TBAF(anh).) has been found to be a highly efficient fluorinating reagent for nucleophilic aromatic fluorinations such as fluorodenitration or halogen exchange (Halex) reaction. The products were formed in high to excellent yields under surprisingly mild reaction conditions and no phenol or ether side-products were detected in these reactions.

• 出版日期2010-2
• 单位南京理工大学