Activity of the investigational fluoroquinolone finafloxacin and seven other antimicrobial agents against 114 obligately anaerobic bacteria

作者：Genzel G H^*; Stubbings W; Stingu C S; Labischinski H; Schaumann R

来源：International Journal of Antimicrobial Agents, 2014, 44(5): 420-423.

DOI：10.1016/j.ijantimicag.2014.07.006

• Anaerobic bacteria
• Investigational fluoroquinolone
• Finafloxacin

The activity of finafloxacin against 73 strains of the Bacteroides fragilis group, 10 other Gram-negative anaerobic rods and 31 Clostridium difficile strains was determined by the broth microdilution technique. The activity was compared with that of moxifloxacin, levofloxacin, ciprofloxacin, clindamycin, imipenem, piperacillin/tazobactam and metronidazole. MIC50/90 values (minimum inhibitory concentration, in mu g/mL, at which 50% and 90% of the isolates tested are inhibited, respectively) for finafloxacin for the different species were determined: B. fragilis group, 0.5/2; other Gram-negative rods, 0.06/0.25; and C. difficile, 4/16. Furthermore, the MICs against 11 selected B. fragilis strains were determined under acidic conditions and resulted in MIC50/90 values for finafloxacin of 0.25/4 mu g/mL. Thus, finafloxacin shows promising activity against several pathogenic species of anaerobes. Furthermore, finafloxacin has increased activity against selected B. fragilis strains under acidic conditions compared with activity at neutral pH.

• 出版日期2014-11
• 单位河北医科大学