Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities

作者:Nayyatip Sanchai; Thaichana Pak; Buayairaksa Mongkol; Tuntiwechapikul Wirote; Meepowpan Puttinan; Nuntasaen Narong; Pompimon Wilart*
来源:International Journal of Molecular Sciences, 2012, 13(4): 5010-5018.
DOI:10.3390/ijms13045010

摘要

A new aristolactam, named enterocarpam-III (10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, 1) together with the known alkaloid stigmalactam (2), were isolated from Orophea enterocarpa. Their structures were elucidated on the basis of interpretation of their spectroscopic data. Compounds 1 and 2 exhibited significant cytotoxicities against human colon adenocarcinoma (HCT15) cell line with IC50 values of 1.68 and 1.32 mu M, respectively.

  • 出版日期2012-4