Delta-like ligand 4 (DII4) predicts the prognosis of clear cell renal cell carcinoma, and anti-DII4 suppresses tumor growth in vivo

作者：Hu Guang Hui; Liu Huan; Lai Peng; Guo Zhui Feng; Xu Liang; Yao Xu Dong; Zheng Jun Hua; Liu Min^*; Xu Yun Fei

来源：International Journal of Clinical and Experimental Pathology, 2014, 7(5): 2143-2152.

• Angiogenesis
• anti-DII4
• clear cell renal cell carcinoma
• Delta-like ligand 4
• prognosis
• tumor growth

The Delta-like ligand 4 (DII4) and Notch signaling pathway plays a key role in embryonic vascular development and tumor growth. In this study, we measured the expression of DII4 in clear cell renal cell carcinoma (ccRCC) and explored the correlation between DII4 and ccRCC. We used sh-DII4 treatment in a nude mouse model to observe the effect that inhibition of the DII4/Notch pathway had on angiogenesis and vasculogenesis. We found upregulation of DII4 to be closely correlated with distant metastasis and worse overall survival. Cox regression analysis showed that DII4 might be a prognostic marker of ccRCC. Blockade of DII4/Notch signaling inhibited tumor growth in the mouse model via anti-angiogenesis and anti-vasculogenesis effects. We concluded that DII4 might be a novel therapeutic target for the treatment of ccRCC.

• 出版日期2014
• 单位同济大学