Posterior cingulate atrophy and metabolic decline in early stage Alzheimer%26apos;s disease

作者：Shima Keisuke; Matsunari Ichiro^*; Samuraki Miharu; Chen Wei Ping; Yanase Daisuke; Noguchi Shinohara Moeko; Takeda Nozomi; Ono Kenjiro; Yoshita Mitsuhiro; Miyazaki Yoshiharu; Matsuda Hiroshi; Yamada Masahito

来源：Neurobiology of Aging, 2012, 33(9): 2006-2017.

DOI：10.1016/j.neurobiolaging.2011.07.009

• Alzheimer%26apos
• s disease
• Atrophy
• Neuroimaging
• Cerebrospinal fluid

To test the hypothesis that Alzheimer%26apos;s disease (AD) patients with posterior cingulate/precuneus (PCP) atrophy would be a distinct disease form in view of metabolic decline. Eighty-one AD patients underwent F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) and structural magnetic resonance imaging (MRI). Positron emission tomography and voxel-based morphometry (VBM) Z-score maps were generated for the individual patients using age-specific normal databases. The patients were classified into 3 groups based on atrophic patterns (no-Hipp-PCP, atrophy in neither hippocampus nor PCP; Hipp, hippocampal atrophy; PCP, PCP atrophy). There were 16 patients classified as no-Hipp-PCP, 55 as Hipp, and 10 as PCP. The Mini Mental State Examination (MMSE) score was similar among the groups. The greater FDG decline than atrophy was observed in all groups, including the no-Hipp-PCP. The PCP group was younger, and was associated with a greater degree of FDG decline in PCP than the others. There are diverse atrophic patterns in a spectrum of AD. In particular, a subset of patients show PCP atrophy, which is associated with greater metabolic burden.

• 出版日期2012-9