A treatment strategy for preventing pouchitis as a postoperative complication of ulcerative colitis: the significance of the management of cuffitis

作者：Hashimoto Takuzo; Itabashi Michio^*; Ogawa Shinpei; Hirosawa Tomoichiro; Bamba Yoshiko; Kaji Sanae; Ubukata Mamiko; Nakao Sayumi; Kameoka Shingo

来源：Surgery Today, 2014, 44(9): 1730-1734.

DOI：10.1007/s00595-014-0974-5

• Ulcerative colitis
• Pouchitis
• Cuffitis

The aim of this study was to examine the risk factors for and to evaluate strategies for preventing pouchitis as a postoperative complication of ulcerative colitis (UC). %26lt;br%26gt;A total of 119 cases of UC in which restorative proctocolectomy with an ileal pouch-anal anastomosis (IPAA) was performed at our institution between 2000 and 2012 was investigated; nine patients in whom it was impossible to close the ileostomy due to an intractable anal fistula or pelvic abscess were excluded. %26lt;br%26gt;The cumulative risk of developing pouchitis 5 years after IPAA with stoma closure was 31.0 %. Significant relationships with pouchitis were found for the surgical indication (p = 0.0126) and surgical method (p = 0.0214). A significant correlation was found between pouchitis and cuffitis. Pouchitis was significantly more common in the cases with cuffitis than in those without (p = 0.0002). There was also a significantly different cumulative incidence observed between the cases with and without cuffitis (p %26lt; 0.0001). In addition, pouchitis had a greater tendency to recur in the cases with cuffitis than in those without (p = 0.2730). %26lt;br%26gt;The cumulative incidence rate of pouchitis was 10.6 % at 1 year, 15.1 % at 2 years and 31.0 % at 5 years. Controlling cuffitis is important to prevent pouchitis.

• 出版日期2014-9