Antimicrobial peptides: Clinical relevance and therapeutic implications

作者：da Silva Fabiano Pinheiro^*; Cesar Machado Marcel Cerqueira

来源：Peptides, 2012, 36(2): 308-314.

DOI：10.1016/j.peptides.2012.05.014

• Cathelicidins
• Defensins
• Vitamin D
• Autoimmunity, Infection and cancer

Antimicrobial peptides (AMPS) are molecules that provide protection against environmental pathogens, acting against a large number of microorganisms, including bacteria, fungi, yeast, virus and others. Two major groups of antimicrobial peptides are found in humans: cathelicidins and defensins. Recently, several studies have furnished information that besides their role in infection diseases, antimicrobial peptides play a role in diseases as diverse as inflammatory disorders, autoimmunity and cancer. Here, we discuss the role of antimicrobial peptides and vitamin D have in such complex diseases and propose their use should be more explored in the diagnosis and treatment of such conditions.

• 出版日期2012-8