Necroptosis: (Last) Message in a Bubble

作者：Vandenabeele Peter^*; Riquet Franck; Cappe Benjamin

来源：Immunity, 2017, 47(1): 1-3.

DOI：10.1016/j.immuni.2017.07.002

RIPK3 kinase-mediated phosphorylation of MLKL pseudokinase is the execution event of necroptosis. Two independent reports-in Immunity (Yoon et al., 2017) and Cell (Gong et al., 2017)-reveal that MLKL affects homeostatic membrane trafficking and necroptosis-enhanced bubble formation involving interaction with the ESCRT machinery.

• 出版日期2017-7-18