DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling

作者：Kim Jung Min; Shin Hong In; Cha Sun Shin; Lee Chang Sup; Hong Bok Sil; Lim Seyoung; Jang Hyun Jun; Kim Jaeyoon; Yang Yong Ryoul; Kim Yun Hee; Yun Sanguk; Rijal Girdhari; Lee Kwon Whaseon; Seo Jeong Kon; Gho Yong Song; Ryu Sung Ho; Hur Eun Mi; Suh Pann Ghill^*

来源：Nature Communications, 2012, 3: 1296.

DOI：10.1038/ncomms2313

Communication between osteoblasts and endothelial cells is essential for bone fracture repair, but the molecular identities of such communicating factors are not well defined. Here we identify DJ-1 as a novel mediator of the cross-talk between osteoblasts and endothelial cells through an unbiased screening of molecules secreted from human mesenchymal stem cells during osteogenesis. We show that DJ-1 stimulates the differentiation of human mesenchymal stem cells to osteoblasts and that DJ-1 induces angiogenesis in endothelial cells through activation of fibroblast growth factor receptor-1 signalling. In a rodent model of bone fracture repair, extracellular application of DJ-1 enhances bone regeneration in vivo by stimulating the formation of blood vessels and new bones. Both these effects are blocked by antagonizing fibroblast growth factor receptor-1 signalling. These findings uncover previously undefined extracellular roles of DJ-1 to promote angiogenesis and osteogenesis, suggesting DJ-1 may have therapeutic potential to stimulate bone regeneration.

• 出版日期2012-12