Aberrant production of soluble co-stimulatory molecules CTLA-4 and CD28 in patients with chronic hepatitis B

作者：Cao Ju; Zhang Liping^*; Huang Shifeng; Chen Pu; Zou Lin; Chen Hui; Xiang Yu; Lai Xiaofei; Ren Guosheng

来源：Microbial Pathogenesis, 2011, 51(4): 262-267.

DOI：10.1016/j.micpath.2011.06.003

• Co-stimulatory molecules
• HBV
• Infection
• Immune response

Co-stimulation signals are critical for anti-viral immunity. Here we investigated whether there is altered expression and the clinical significance of soluble co-stimulatory molecules in patients with chronic HBV infection. Serum concentrations and ex vivo production of soluble CTLA-4, CD28, CD80 and CD86 were analyzed by enzyme-linked immunosorbent assay. Serum sCTLA-4 and sCD28 concentrations in all chronic HBV patients were significantly higher than concentrations in healthy control subjects. Serum sCTLA-4 and sCD28 correlated significantly with alanine aminotransferase in all chronic HBV patients. Upon mitogen stimulation of peripheral blood mononuclear cells, the percentage increases in ex vivo production of sCD28 and sCD80 and the percentage decrease in sCTLA-4 release were all significantly lower in chronic HBV patients than those in healthy subjects. The aberrant production of soluble costimulatory molecules should reflect the dysregulation of T cell activation and is related to the pathogenesis and severity of chronic HBV infection.

• 出版日期2011-10
• 单位重庆医科大学