A new -glucuronidase inhibiting butyrolactone from the marine endophytic fungus Aspergillus terreus

作者：Haroon M H; Premaratne S R; Choudhry M Iqbal; Dharmaratne H R W^*

来源：Natural Product Research, 2013, 27(12): 1060-1066.

DOI：10.1080/14786419.2012.708659

• Aspergillus terreus
• Laurencia ceylanica
• butyrolactone
• 3-hydroxy-4-(4-hydroxyphenyl)-5-methoxycarbonyl-5-(4-hydroxy-3-formylben zyl)-2
• 5-dihydro-2-furanone
• -glucuronidase

An endophytic fungus Aspergillus terreus, var. boedijnii (Blochwitz) was isolated from red marine alga Laurencia ceylanica, J. Agardh, cultured in large scale and extracted with EtOAc. The above-mentioned extract yielded a new butyrolactone, 3-hydroxy-4-(4-hydroxyphenyl)-5-methoxycarbonyl-5-(4-hydroxy-3-formylbenzyl)-2,5-dihydro-2-furanone (1), along with the previously reported nine compounds, butyrolactone-1 (2), 6-hydroxymellin (3), (3R, 4R)-6,7-dimethoxy-4-hydroxymellin (4), (+)-territonin (5), (+)-territonin-A (6), (+)-asterrelenin (7), (+)-terrein (8), oleic acid (9) and glucopyranosyl--sitosterol (10), on column and preparative thin-layer chromatography. Compounds 1-8 were subjected to -glucuronidase inhibitory activity test, and 1 showed a remarkable activity, while 2 and 7 showed moderate activity.

• 出版日期2013-6-1