alpha-Aminoamides as ligands in Goldberg amidations

作者：Mitra Aurpon W; Hansen Marvin M; Laurila Michael E; Kolis Stanley P; Martinelli Joseph R^*

来源：Tetrahedron Letters, 2013, 54(48): 6580-6583.

DOI：10.1016/j.tetlet.2013.09.099

• Amidation
• Aminoamide
• Cross-coupling
• Cu catalysis
• Acetamide

alpha-Aminoamides are shown to be useful as ligands in Goldberg amidations. A number of alpha-aminoamides are examined and the importance of substitution on the alpha-aminoamides is explored. Acetamide is focused on as the nucleophilic coupling partner due to its low cost, stability and convenience as a protecting group. The initial substrate scope for these catalysts is explored and includes electronically activated and deactivated aryl bromides, however o-substituted aryl bromides are problematic.

• 出版日期2013-11-27