Asymmetric Reduction of beta-Ketoesters and Chiral beta-Iminoesters: Impact of a alpha-Quaternary Stereocenter

作者：Almahli Hadia; Hendra Frederic; Troufflard Claire; Cave Christian; Joseph Delphine; Delarue Cochin Sandrine^*

来源：Chirality, 2011, 23(3): 265-271.

DOI：10.1002/chir.20909

• asymmetric synthesis
• diastereoselectivity
• beta-aminoesters
• beta-hydroxyesters

Diastereomeric reduction of nonactivated, hindered beta-keto and chiral beta-iminoesters are described. The influence of a alpha-stereocontrolled center on the efficiency and stereoselectivity of the reduction was studied. Reaction conditions were optimized to synthesize beta-hydroxy- and beta-aminoesters in good yields. In the case of chiral beta-iminoesters, influence of matched/mismatched diastereomeric pairs has been assessed. Chirality 23:265-271, 2011.

• 出版日期2011-3