Association of urinary neopterin, neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios with long-term survival of patients with breast cancer

作者：Melichar Bohuslav; Studentova Hana; Vitaskova Denisa; Sramek Vlastislav; Krcmova Lenka Kujovska; Peskova Eliska; Solichova Dagmar; Kalabova Hana; Ryska Ales; Hruzova Klara; Havlik Roman

来源：Pteridines, 2016, 27(3-4): 59-65.

DOI：10.1515/pterid-2016-0001

• breast cancer
• lymphocyte-to-monocyte ratio
• neopterin
• neutrophil-to-lymphocyte ratio
• platelet-to-lymphocyte ratio

The immune response crucially determines the survival of patients with malignant tumors including breast carcinoma. The aim of the present study was to evaluate retrospectively an association of peripheral blood cell count (PBC)-derived ratios and urinary neopterin concentration with prognosis in breast cancer patients. Urinary neopterin, neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR) and platelet-to-lymphocyte ratio (PLR) were retrospectively analyzed in a cohort of 474 breast cancer patients. NLR and PLR correlated positively with each other and negatively with LMR, but no correlation between neopterin concentrations and PBC-derived ratios was observed. Increased urinary neopterin concentration was a significant predictor of poor survival in patients with active disease, but PLR, NLR or LMR were not significantly associated with survival in multivariate analysis. In conclusion, increased urinary neopterin was a significant predictor of poor survival in patients with breast cancer and active disease.

• 出版日期2016-12