Association of matrix metalloproteinase 9 genotypes and cardiovascular disease risk factors with serum matrix metalloproteinase 9 concentrations in Taiwanese individuals

作者：Wu Semon; Hsu Lung An; Teng Ming Sheng; Lin Jeng Feng; Chang Hsien Hsun; Chang Pi Yueh; Hu Chiao Feng; Ko Yu Lin^*

来源：Clinical Chemistry and Laboratory Medicine, 2010, 48(4): 543-549.

DOI：10.1515/CCLM.2010.099

• cardiovascular risk factors
• metalloproteinases
• polymorphism

Background: Circulating concentrations of matrix metalloproteinase 9 (MMP-9) are associated with cardiovascular disease mortality in patients with coronary artery disease. We investigated the determinants of MMP-9 concentrations by analyzing MMP-9 genotypes and risk factors for cardiovascular disease.
Methods: A total of 596 individuals were recruited for this study. Six single nucleotide polymorphisms (SNP) with coverage of the MMP-9 gene region were analyzed; and two genotypes, rs3918242-TT and rs2274756-AA, which were in nearly complete linkage disequilibrium, were associated with higher MMP-9 values (p = 0.007 and p = 0.008, respectively). In age-and gender-adjusted regression models, MMP-9 concentrations were positively associated with the homeostasis model assessment of insulin resistance (HOMA-IR) index and triglyceride concentrations, fasting serum insulin, fasting plasma glucose, C-reactive protein, fibrinogen, and serum amyloid A. By multivariate analysis, rs2274756 genotypes, age, smoking status, fibrinogen and fasting plasma glucose concentrations were all independently associated with MMP-9 (p = 0.007, p = 0.033, p = 0.003, p = 0.013, and p = 0.012, respectively).
Conclusions: The rs2274756-AA and rs3918242-TT genotypes, younger age, current smoking status and increased fasting plasma glucose, and fibrinogen concentrations were independently associated with high serum MMP-9 concentrations in Taiwanese individuals. Clin Chem Lab Med 2010;48:543-9.

• 出版日期2010-4
• 单位长春大学