A new cytotoxic prenylated dihydrobenzofuran derivative and other chemical constituents from the rhizomes of Atractylodes lancea DC

作者：Duan Jin ao^*; Wang Liuying; Qian Shihui; Su Shulan; Tang Yuping

来源：Archives of Pharmacal Research, 2008, 31(8): 965-969.

DOI：10.1007/s12272-001-1252-z

• Atractylodes lancea
• asteraceae
• constituent
• atractylenolide
• dihydrobenzofuran
• cytotoxicity

A new prenylated dihydrobenzofuran derivative (1), was isolated from the rhizomes of Atractylodes lancea DC (Asteraccae), along with ten known Compounds, including atractylencilide II (2), phi-taraxasteryl acetate (3), taraxerol acetate (4). beta-sitosterol (5), stigmasterol (6), beta-eudesmol (7), atractylenolide III (8), atractylenolide IV (9), daucosterol (10), and stigmasterol 3-O-beta-D-glucopyranoside (11). The structure of the new compound (1) was elucidated as trans-2-hydroxyisoxypropyl-3-hydroxy-7-isopentene-2,3-dihydrobenzofuran- 5-carboxylic acid by the combination of 1D, 2D NMR analysis and mass spectrometry, and it was the first reported 2,3-dihydrobenzofuran derivative having a carboxyl residue at C-5 and ail isopentene moiety at C-7 contemporaneously. In addition, compound 1 exhibited significant cytotoxicity against cancer cell lines HCT-116 and MKN-45.

• 出版日期2008-8
• 单位江苏省中医药研究院; 南京中医药大学; 江苏大学