A mitochondria-targeting hetero-binuclear Ir(iii)-Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells

作者：Ouyang, Cheng; Chen, Lei; Rees, Thomas W.; Chen, Yu^*; Liu, Jiankang; Ji, Liangnian; Long, Jiangang^*; Chao, Hui^*

来源：Chemical communications, 2018, 54(49): 6268-6271.

DOI：10.1039/c8cc02795a

• DEATH
• DRUG
• PATHWAYS

A hetero-binuclear Ir(iii)-Pt(ii) complex was developed as an antitumor agent. In vitro cytotoxicity results indicated that this complex was effective against cisplatin-resistant tumor cells. Mechanism experiments showed that it can overcome cisplatin resistance by increasing cellular uptake, targeting mitochondria, and inducing cell necrosis.

• 出版日期2018-6-21
• 单位西安交通大学; 中山大学