科研之友
微信
新浪微博
Facebook
分享链接
摘要
The aim of this review is to highlight updated results on the biologically active saponins from Leguminosae-Mimosoideae. Acacic acid-type saponins (AATS), is a class of very complex glycosides possessing a common aglycon unit of the oleanane-type (acacic acid = 3 beta, 16 alpha, 21 beta trihydroxy-olean-12-en-28 oic acid), having various oligosaccharide moieties at C-3 and C-28 and an acyl group at C-21. About sixty molecules of this type have been actively explored in recent years from Leguminosae family, from a chemical point of view and some fifty were reported to possess cancer related activities. These include cytotoxic/antitumor, immunomodulatory, antimutagenic, and apoptosis inducing properties and appear to depend on the acylation and esterification by different moieties at C-21 and C-28 of the acacic acid-type aglycone. One can observe that the (6S) configuration of the outer monoterpenyl moiety (MT) seems more potent in mediating high cytotoxicity than its (6R) isomer. Furthermore, the trisaccharide moiety {beta-d-Xylopyranosyl-(1 -> 2)-beta-d-Fucopyranosyl-(1 -> 6)- N-Acetamido 2-beta-d-Glucopyranosyl-} at C-3, the tetrasaccharide moiety {beta-d-Glucopyranosyl-(1 -> 3)-[alpha-L-Arabinofuranosyl-(1 -> 4)]-alpha-l-Rhamnopyranosyl-(1 -> 2)-beta-d-Glucopyranosyl} at C-28 of the aglycone, and the inner MT hydroxylated at its C-9, having a (6S) configuration can be important substituent patterns for the induction of apoptosis of AATS. Because of their interesting cytotoxic/apoptosis inducing activity, some AATS can be useful in the search for new potential antitumor agents from Fabaceae. Furthermore, the sequence 28-O-{Glc-(1 -> 3)-[Ara(f)-(1 -> 4)]-Rha-(1 -> 2)-Glc-Acacic acid}, often encountered in the genera Acacia, Albizia, Archidendron, and Pithecellobium may represent a chemotaxonomic marker of the Mimosoideae subfamily.
- 出版日期2011-12
