Diastereoselective synthesis of N-sulfinyl alpha-aminophosphine sulfides and phosphines

作者：Zhang Wei; Gilbertson Scott R^*

来源：Tetrahedron Letters, 2017, 58(23): 2175-2177.

DOI：10.1016/j.tetlet.2017.03.067

• Aminophosphine
• Sulfinyl phosphine
• Phosphine oxide
• Phosphine sulfide

The diastereoselective synthesis of N-sulfinyl alpha-aminophosphine sulfides and phosphines is reported. These molecules are synthesized by formation of sulfinyl imine followed by diastereoselective addition of a diphenylphosphine sulfide. The product N-sulfinyl alpha-aminophosphine sulfides can be converted to phosphines through removal of the sulfur by reaction with Raney nickel. Hydrolysis of the sulfinyl group provides an amine that can then be attached to other ligands or structural scaffolds.

• 出版日期2017-6-7