A Mitochondrial Expatriate: Nuclear Pyruvate Dehydrogenase

作者：de Boer Vincent C J^*; Houten Sander M

来源：Cell, 2014, 158(1): 9-10.

DOI：10.1016/j.cell.2014.06.018

The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate into acetyl-CoA, a critical step in metabolism. Sutendra et al. now demonstrate that PDC can translocate from the mitochondria to the nucleus to provide acetyl-CoA necessary for histone acetylation, suggesting a new pathway for mitochondrial-nuclear communication.

• 出版日期2014-7-3