Amelanotic melanoma in dogs: A retrospective study of 35 cases (2004-2010) and immunohistochemical characterization

作者：Rolim Veronica M; Casagrande Renata A; Watanabe Tatiane T; Wouters Angelica T; Wouters Flademir; Sonne Luciana; Driemeier David^*

来源：Pesquisa Veterinaria Brasileira, 2012, 32(4): 340-346.

DOI：10.1590/S0100-736X2012000400011

• Amelanotic melanoma
• melanocytic tumor
• immunohistochemistry
• dog

Rolim V. M., Casagrande R. A., Watanabe T. T., Wouters A. T., Wouters F., Sonne L. %26 Driemeier D. 2012. [Amelanotic melanoma in dogs: A retrospective study of 35 cases (2004-2010) and immunohistochemical characterization.] Melanoma amelanotico em caes: estudo retrospectivo de 35 casos (2004-2010) e caracterizacao imuno-histoquimica. Pesquisa Veterinaria Brasileira 32(4): 340-346. Setor de Patologia Veterinaria, Faculdade de Veterinaria, Universidade Federal do Rio Grande do Sul, Av. Bento Goncalves 9090, Porto Alegre, RS 91540-000, Brazil. E-mail: [e-mail] %26lt;br%26gt;Melanomas are aggressive tumors of melanocytes. They are common in dogs and involve mainly the oral cavity, mucocutaneous junction, and skin. Furthermore, these tumors could be highly pigmented or lack pigment. The biopsies archives from SPV-UFRGS, 2004 to 2010, were retrieved and melanocytic neoplasms in dogs were revised. A retrospective study of 35 cases of amelanotic melanomas (AM) was performed, also immunohistochemistry (IHC) characterization was evaluated. The dogs more affected were mixed breed followed by Poodle, Dachshund and Cocker Spaniel. The average age of the dogs was 10.7 years (5-18 years in age) and there was no sex predilection. The locations of the neoplasms were the oral cavity (57.1%) and digits (17.1%). Histologically, 40% were classified as epithelioid, 34.3% mixed and 25.7% spindle. The positive immunostaining for vimentin, S-100 protein and melan-A were 86.6%, 70%, and 56.6% respectively. These results indicated the most affected dogs with AM were elderly. Epiteliod classification was the most observed histologically. It is important to perform IHC, due to lacking of differentiation of AM, mainly, anti S-100 protein that showed to be the best option of positive marker, even better to Melan-A.

• 出版日期2012-4