A Maillard Approach to 2-Formylpyrroles: Synthesis of Magnolamide, Lobechine and Funebral

作者:Yuen Tsz Ying; Eaton Samantha E; Woods Tom M; Furkert Daniel P; Choi Ka Wai; Brimble Margaret A*
来源:European Journal of Organic Chemistry, 2014, 2014(7): 1431-1437.
DOI:10.1002/ejoc.201301639

摘要

A convenient synthesis of the traditional medicine constituents magnolamide, lobechine and funebral is described. Construction of the 2-formylpyrrole core of these natural products was achieved by means of a Maillard reaction, involving condensation of the sugar surrogate, dihydropyranone 9, with the requisite primary amines. This approach offers a very direct and general route to the 2-formylpyrrole ring system.

  • 出版日期2014-3